- Were all important decision options and outcomes clearly specified?
- Was the evidence relevant to each decision option identified, validated and combined in a sensible and explicit way?
- Are the relative preferences that key stakeholders attach to the outcomes of decisions (including benefits, risks and costs) identified and explicitly considered?
- Is the guideline resistant to clinically sensible variations in practice?
Reference: Evidence-based Medicine – Sackett, Richardson, Rosenberg and Haynes.