|1. Patient or problem||2. Intervention (a cause, prognostic factor, treatment, etc.)||3. Comparison intervention (if necessary)||4. Outcome(s)|
|Tips for building||Starting with your patient, ask “how would I describe a group of patients similar to mine?”||Ask “which intervention am I considering?” Be specific.||Ask “what is the main alternative to compare with the intervention?” Be specific.||Ask “what can I hope to accomplish?” or “what could this exposure really affect?” Be specific.|
|Example||“In patients with heart failure from dilated cardiomyopathy who are in sinus rhythm…”||“…would adding anticoagulation with warfarin to standard heart failure therapy…”||“…when compared with standard therapy alone…”||“…lead to lower mortality or morbidity from thromboembolism. Is this enough to be worth the increased risk of bleeding?”|
Reference: Evidence-based Medicine – Sackett, Richardson, Rosenberg and Haynes.