Sjögren's
syndrome- F>M 9:1
- 15-65
- Gritty/dry eyes - Schirmer's test
- Dry mouth
- Lymphocytic infiltrates on biopsy/leucopoenia
- Serum autoantibodies
- RF
- ANF
- Ro(85%)
- La(60%)
- HLA DR3 (60%)
3 of 4 possible diagnosis
4 0f 4 definite diagnosis
Primary Sjogrens
- Non-erosive arthritis
- Raynauds
- Purpuric vasculitis lower legs
- Decreased pulmonary function
Sjogrens-associated overlap syndromes
- SLE
- Polymyositis
- Scleroderma
- Primary biliary cirrhosis
Secondary Sjogrens
RA: Erosive arthritis