Antipsychotics
– relative adverse effects|
Drug |
Sedation |
Extra-pyramidal |
Anti-cholinergic |
Hypotension |
Cardiac toxicity |
Prolactin elevation |
|
Chlorpromazine |
+++ |
++ |
++ |
+++ |
++ |
+++ |
|
Promazine |
+++ |
+ |
++ |
++ |
+ |
++ |
|
Thioridazine |
+++ |
+ |
+++ |
+++ |
+++ |
++ |
|
Fluphenazine |
+ |
+++ |
++ |
+ |
+ |
+++ |
|
Perphenazine |
+ |
+++ |
+ |
+ |
+ |
+++ |
|
Trifluoperazine |
+ |
+++ |
+/- |
+ |
+ |
+++ |
|
Flupenthixol |
+ |
++ |
++ |
+ |
+ |
+++ |
|
Zuclopenthixol |
++ |
++ |
++ |
+ |
+ |
+++ |
|
Haloperidol |
+ |
+++ |
+ |
+ |
+ |
+++ |
|
Droperidol |
++ |
+++ |
+ |
+ |
+ |
+++ |
|
Benperidol |
+ |
+++ |
+ |
+ |
+ |
+++ |
|
Sulpiride |
- |
+ |
+/- |
- |
- |
+++ |
|
Pimozide |
+ |
+ |
+ |
+ |
+++ |
+++ |
|
Loxapine |
++ |
+++ |
+ |
++ |
+ |
+++ |
|
Clozapine |
+++ |
- |
+++ |
+++ |
+ |
- |
|
Risperidone |
+ |
+ |
+ |
++ |
- |
+++ |
|
Sertindole* |
- |
- |
- |
+++ |
+++ |
- |
|
Olanzapine |
++ |
+/- |
+ |
+ |
- |
+ |
|
Quetiapine |
++ |
- |
+ |
++ |
- |
- |
|
Amisulpride |
- |
+ |
- |
- |
- |
+++ |
|
Zotepine |
+++ |
++ |
+ |
++ |
++ |
++ |
|
Ziprasidone** |
+ |
+/- |
- |
+ |
+ |
+ |