Management
of peptic ulcer
H Pylori eradication has a number of problems:
- Eradication regimens are not 100% successful.
- Metronidazole resistance is a significant problem, sub-optimal treatment will increase this risk and it may increase with poor compliance.
- Treatment regimes are not without their problems e.g. GI intolerance, alcohol interaction, pseudomembranous colitis.
- Failure to take the full course will result in unsuccessful eradication.
- In patients sensitive to penicillin, the regimen containing clarithromycin may be an alternative. Other regimens may be found in the BNF (Chapter 1, Section 1.3).