- Blood count/film reported as suggestive of acute leukaemia or chronic myeloid leukaemia.
- Lymphadenopathy (> 1 cm) persisting for 6 weeks.
- Hepatosplenomegaly
- Bone pain associated with anaemia and a raised ESR (or plasma viscosity).
- Bone x rays reported as being suggestive of myeloma.
- Constellation of 3 or more of the following symptoms: Fatigue, night sweats, weight loss, itching, breathlessness, bruising, recurrent infections, bone pain.