Cancer and genetics

Number of Relatives	Age at diagnosis	Refer to Genetics
1 (first degree)	> 40 years	No
1 (first degree)	< 40 years	Yes
1 (first degree) bilateral		Yes
1 Male (first degree)	Any age	Yes
≥ 2 (one first degree)	Any age	Yes
FH with Jewish ancestry		Yes
Strong FH on paternal side		Yes
Tumour associations - ovary, endometrium, prostate, bowel		Yes

A close relative is a first degree relative (parent, sib, child) or second degree relative (aunt, uncle, grandparent).
If there is a strong family history on the paternal side, more distant relationships maybe relevant.
Affected relatives should be on the same side of the family.
A lesser family history of cancer may still significantly increase the risk if the family is of Jewish or non-white ethnic origin. If in
doubt, please discuss with the Clinical Genetics Service.
Sarcoma <45, glioma or childhood adrenal carcinoma may also be relevant.

Number of relatives	Age at diagnosis	Refer to Genetics
1 fdr	>50 years	No
1 fdr	< 50 years	Yes
2 fdr (includes both parents)	Any age	Yes
1fdr and 1 sdr	Any age	Yes
3+ relatives	Any age	Yes
FH of known hereditary colorectal cancer syndrome (e.g. HNPCC, FAP)	Any age	Yes

HNPCC related cancers include endometrial, gastric, ovarian, pancreatic and urothelial.
2fdr (includes both parents) - Whilst this is for both parents any other relatives must be on the same side of the family.

Number of Relatives	Age at diagnosis	Refer to Genetics
1 fdr no other FH of cancer	Any age	No
2 fdr	Any age	Yes
1fdr and 1sdr	Any age	Yes
1fdr with ovarian and 1 or more with breast or colorectal cancer	Any age	Yes

For any queries about a family history of any particular cancer, if in doubt, contact genetics.