MethotrexateWhy are you taking it?
Methotrexate acts by damping down inflammation in joints. It has no direct pain relieving effect, so you will need to continue your other arthritis tablets, at least for some time. It may take from 6 to 12 weeks to get the full effect from the methotrexate. If it is suitable, you can stay on treatment for several years if necessary
How and when is it to be taken?
Methotrexate is only taken ONCE A WEEK. The usual dose is between 5 mg and 20 mg each week - all tablets taken together, on the same day each week. Most patients take their Methotrexate on a Saturday.
Methotrexate is available in two tablet sizes 2.5 mg and 10 mg. It is very important to know which you have been given. We may suggest a weekly injection instead of tablets in some cases.
Usually, you will also be prescribed a WEEKLY tablet of Folic Acid (5 mg). This is to be taken 3 days after taking the Methotrexate. It counteracts some of the possible side-effects of Methotrexate. If you forget to take the tablets on your regular day, take them the next day. Alcohol can increase the risk of side-effects and is best kept to a minimum.
Can you take other medicines with methotrexate?
It is safe to take methotrexate with most other medicines. Always tell the doctor if you are taking medicines for epilepsy or psoriasis. Some antibiotics are best avoided if you are on methotrexate. Therefore, if you see a doctor for infections or any other problem, tell him you are on methotrexate.
Are there any side effects, and what are they?
All medications can cause side-effects, so it is a question of balancing the risk of side-effects against the benefits of treatment. Possible side-effects include:
- Nausea and sickness, which often settles as you get used to the tablets.
- Mouth ulcers or an unusually sore mouth and throat .
- Breathlessness, fever, chills or sweating which you should report to your nurse or doctor.
- Blood and liver function problems, which is why you have the regular blood tests.
Where appropriate we advise you to use a reliable method of contraception during treatment and for six months after stoipping Methotrexate.
Why is careful monitoring so important?
Monitoring of the effects of your new treatment is important and we need to check your blood regularly - this is usually weekly for the first month, then monthly. If unable to attend, please telephone for another appointment.
If you have any questions, queries or worries about your treatment, please contact your local rheumatology nurse.