1. Were all important decision options and outcomes clearly specified?
  2. Was the evidence relevant to each decision option identified, validated and combined in a sensible and explicit way?
  3. Are the relative preferences that key stakeholders attach to the outcomes of decisions (including benefits, risks and costs) identified and explicitly considered?
  4. Is the guideline resistant to clinically sensible variations in practice?

Reference: Evidence-based Medicine - Sackett, Richardson, Rosenberg and Haynes.